An ongoing EGPA Treatment Research Study by GSK for people with an EGPA diagnosis

NOW ENROLLING:

OCEAN study for adults with EGPA

Do you have eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome? The OCEAN clinical research study is looking for participants who are 18 years of age or older with EGPA that has worsened or returned after previous treatment. See if you’re eligible by taking this 10 minute survey.

Take The Survey

About the OCEAN Study

The OCEAN study is testing an investigational drug to see how it works in adults with EGPA that has worsened or returned after previous treatment. An investigational drug is one that is not yet approved for use by the general public.

Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome) is a condition caused by inflammation as a result of high numbers of certain types of cells in your blood or in your tissues. In most people, EGPA affects the lungs, causing breathing and lung issues, but it can also affect other organs in the body. The exact cause of EGPA is unknown, but an overactive immune system may cause inflammation.

EGPA Medical research for people dealing with Eosinophilic Granulomatosis with Polyangiitis and their symptoms have gotten worse after EGPA treatment

Who can participate in the OCEAN study?

You may qualify for the OCEAN study if you:

  • EGPA clinical trial looking for those 18 years of age or older diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and has worsened or returned after previous treatment Are at least 18 years of age or older
  • EGPA research study participants must have a eosinophilic granulomatosis with polyangiitis (EGPA) diagnosis Have EGPA that has worsened or returned after previous treatment
  • Individuals with Eosinophilic Granulomatosis with Polyangitis must have worsened or returned after previous EGPA treatment Are currently taking a corticosteroid or immunosuppressant treatment

This is not a complete list of study requirements. The study doctor will review the full requirements for this study with you.

Take The Survey

What can I expect if I decide to participate?

If you qualify, you will be involved with the study approximately 60 weeks (a little over 1 year).

Screening Period

(1 to 4 weeks)
  • You will be asked about your history of EGPA and treatment
  • Go over your general medical history
  • Go over electronic Diary (eDiary) registration and training

Study Treatment Period

(52 weeks)
  • You will be randomly assigned (by chance; like flipping a coin) to a study group to receive either the investigational study drug (depemokimab) or mepolizumab (a drug approved to treat EGPA).
  • Either the study drug (depemokimab) or mepolizumab will be given as injections during the 52-week treatment period.
  • Both study groups will also receive placebo injections plus standard EGPA therapy as prescribed by a doctor.

Follow-Up Period

(After about 4 weeks)
  • You will receive a follow-up phone call so study staff can ask you safety questions.

What safeguards are in place to help protect study participants?

There are rules in place to help protect the rights, safety, and well-being of people who volunteer for research studies. These rules are put in place to make sure studies follow strict scientific and ethical guidelines. Before a clinical research study can begin, a review board must review the study. This group is called an IRB or institutional review board, and is made up of doctors, scientists, and members of the community.

The Eosinophilic Granulomatosis with Polyangiitis (formerly Churg-Strauss Syndrome) research study by GSK is IRB-approved

See if you’re eligible for the OCEAN study by taking this 10 minute survey.

Take The Survey →

Is participation mandatory?
Does it cost anything?

Taking part in this study is totally voluntary and you may stop at any time for any reason. Additionally during the study, you do not have to pay for the study drug or mepolizumab, study supplies, or tests that are part of the OCEAN study.

Participating in the EGPA medical research study is completely voluntary

What is a Research Study?

Before new treatments and medications are made available to the public, they first have to be studied to make sure they’re safe and effective. That’s where research studies come in. A research study, or clinical trial, is a type of medical research that’s used to determine how well a new treatment or medication will work. The goal is simple: To help doctors find safe and effective ways to treat, diagnose or even prevent all kinds of medical conditions.

Learn More
Ongoing EGPA clinical trials to help improve EGPA treatment

Where can I learn more?

If you’re interested in learning more about the OCEAN study, including potential risks and benefits of participation, you can find additional details at CTGOV.

See if you’re eligible for the OCEAN study by taking this 10 minute survey.

Take The Survey →